Bioinformatics Multiple Choice Questions MCQs with Answers

1. All are sequence alignment tools except:
a. Rasmol
d. Clustal W
Answer: a. Rasmol

2. The alignment method used to identify the Filaggrin gene mutation is?
a. Multiple sequence alignment
b. Pair-wise alignment
c. Global alignment
d. Local alignment
Answer: b. Pair-wise alignment

3. The science of collecting and analyzing complex biological data such as genetic codes is known as…?
a. Bioinformatics
b. histology
c. microbiology
d. entomology
Answer: a. Bioinformatics

4. Who is the father of Bioinformatics?
a. Gilbert
b. Hopkin
c. Michael Faraday
d. Margaret O. Dayhoff
Answer: d. Margaret O. Dayhoff

5. Which is a multiple sequence alignment tool?
a. Clustal W
b. Chime
c. Dismol
d. PDB
Answer: a. Clustal W

6. When did Smith-Waterman describe the algorithm for local alignment?
a. 1950
b. 1970
c. 1981
d. 1925
Answer: c. 1981

7. Which of the following is a chemical method?
a. DNA chip sequencing
b. Eeman’s method
c. Sanger’s method
d. Maxam-Gilbert method
Answer: d. Maxam-Gilbert method

8. Which of the following is called as dideoxynucleotide chain termination method?
a. DNA chip sequencing
b. Eeman sequencing
c. Sanger sequencing
d. Automated sequencing
Answer: c. Sanger sequencing

Recommended: Bioinformatics Online Practice Test

9. How many ddNTPs are used in Sanger’s method?
a. Two
b. Four
c. One
d. Three
Answer: b. Four

10. In automated DNA sequencing….?
a. Radio labeled dNTPs are used
b. Radio labeled ddNTPs are used
c. Fluorescently labeled dNTPs are used
d. Fluorescently labeled ddNTPs are used
Answer: c. Fluorescently labeled dNTPs are used

11. In the Maxam-Gilbert method chemical used for cytosine alteration is?
a. Formic acid
b. Hydrazine
c. Dimethyl sulfate
d. Piperidine
Answer: b. Hydrazine

12. The chemical used for strand cleavage in the Maxam-Gilbert method is:
a. Piperidine
b. Hydrazine
c. Formic acid
Answer: a. Piperidine

13. Which task is performed in Bioinformatics?
a. Analysis of gene variation
b. Mapping and analyzing DNA
c. Analysis of protein structure
d. All of these
Answer: d. All of these

14. Choose the correct example of Homology and similarity tool:
a. RasMol
Answer: b. BLAST

15. SWISS-PROT is an annotated protein sequence database established in…?
a. 1997
b. 1987
c. 1978
d. 1990
Answer: b. 1987

16. The human genome contains approximately…?
a. 5 billion base pairs
b. 3 billion base pairs
c. 10 billion base pairs
d. 7 billion base pairs
Answer: b. 3 billion base pairs

17. Which of the following tools is used to analyze your protein sequence motifs?
d. Pattern hunter
Answer: b. COPIA

18. Which of the following is the first biological database?
a. MySQL
b. GenBank
c. BioBank
d. Informix
Answer: b. GenBank

19. The deposition of cDNA into the inert structure is known as…?
a. DNA polymerase
b. DNA probes
c. DNA fingerprinting
d. DNA microarrays
Answer: d. DNA microarrays

20. Genomic information which is used to study individual responses to drugs is known as…?
a. Genomics
b. Pharmacogenetics
c. Cheminformatics
d. Pharmacogenomics
Answer: d. Pharmacogenomics

21. Choose the correct definition of Proteomics:
a. Study of the structure and function of vitamins
b. Study of Biomolecules
c. Study of the structure and function of proteins
d. Study of the entire set of genes
Answer: c. Study of the structure and function of proteins

22. The process of finding the relative location of genes on a chromosome is known as…?
a. Chromosome mapping
b. Genome walking
c. Gene tracking
d. Genome mapping
Answer: d. Genome mapping

23. A kind of bioinformatics modeling that predicts the three-dimensional structure of any complex – this definition is related to…?
a. Molecular fitting
b. Bio docking
c. Gene docking
d. Molecular docking
Answer: d. Molecular docking

24. Which of the following scientist coined the term bioinformatics?
a. Pauline Hogeweg
b. J.D Watson
c. Frederic Sanger
d. Margaret Dayhoff
Answer: a. Pauline Hogeweg

25. A type of laboratory that involves applied or computational mathematical analyses completed on a computer-generated model generally offline is referred to as:
a. Wet Lab
b. Insilico
c. Dry Lab
d. All of these
Answer: c. Dry Lab

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